Annoying Orange (voiced by Dane Boedigheimer) - The main protagonist of the series. He's annoying, obnoxious, and partial to terrible puns. But deep down, Orange always means well, even though his boredom often drags his friends into ridiculous adventures. This series shows another side of Orange outside of his annoying YouTube self, and casts him as the role of a whacky hero (who's also annoying).
- Annoying Orange will meet Pooh, Thomas, Twilight Sparkle in Winnie the Pooh and the Care Bear's Adventures in Wonderland.
- Annoying Orange will make his guest starring appearances in some of Thomas' Adventures Series.