Apocalypse, real name En Sabah Nur, is the first mutant. He was a pharaoh of Egypt. He and Nighlock respect each other.
- it is reveal in Weekenders Adventures of Code Red Apocalypse that it was the Dazzlings who had locked him away for ten thousand years.
- Apocalypse will have his revenge on the Dazzlings in Thomas and Twilight Sparkle's Adventures of X-Men Apocalypse.
- His original horsemen consisted of Magneto, Storm(X-Men), Psylock, and Archangel.
- Apocalypse's horsemen in Weekenders Adventures of Code Red Apocalypse will consist of WarMyotismon, DestroyerEtemon, Azula as Storm Fire, and once again Archangel.
- He will be Ryan's enemy in Ryan F-Freeman's Adventures of Transformers: Prime.
- He will help Ryan and the gang in Crash's, Thomas' and Ryan's Adventures of LEGO Dimensions.
- Apocalypse will appear in Age of Darkness, where he makes Nighlock the Horseman of War(turning him into Dark Nighlock), Riptide(X-Men first Class) the Horseman of Pestilience, Carnage the Horseman of Death, and Elsa the Horseman of Famine to take over the world.
"Everything they've built will fall! And from the ashes of their world, we'll build a better one!"
- Apocalypse when Magneto unleashed his full power.