Brain is Penny's dog and despite being a dog, he is as clever as a human being. He is also her best friend and her sidekick and he always accompanies her to every mission. As always, he is a master of disguise and usually Gadget mistakes him for a MAD-Agent in disguise.
- Brain, alongside Inspector Gadget & Penny will meet Emerl & his friends in Team Robot's Misadventures Of Thomas & Friends: Tale of the Brave & Team Robot In Pokemon XY The Series.
- Brain is voiced by Scott McCord