Doctor Nitrus Brio (also known as N. Brio, or simply Brio) is a scientist who formerly worked underDoctor Neo Cortex. Brio's loyalty has fluctuated throughout the series, working on his own accord inCrash Bandicoot 2: Cortex Strikes Back, with Doctor Nefarious Tropy in Crash Twinsanity and even returning to Cortex's side in Crash: Mind Over Mutant. His name is a play on the word "embryo" (a fact that he himself alludes to in Crash: Mind Over Mutant).