Dr. Calico is the main villain in the fictional TV show Bolt from the eponymous Disney film and also serves as the final boss of the official videogame, which is based from the movie within the movie.
He's a charismatic evil genius with a mutated green eye. It is unknown how he got a green eye. He might have been born with it, or it might have been the result of some accidental mutation. It unknown whether or not Dr. Calico had any powers, though it is unlikely.