Neo Periwinkle Cortex was born to a family of circus clowns, but shunned entertaining others in favor of scientific study. At the age of 3, a group of performers tattooed an N on his forehead for "Nerd". After a explosion and Cortex is left without a family, he enrolled at Madam Amberly's Academy of Evil where he met Nitrus Brio. Even in adulthood, Dr. Cortex was still ridiculed by those around him. So to show the people he has what it takes, he hatches a plot to take over the world. With the help of Dr. Brio and his Evolvo-ray (a machine that can zap animals up the evolutionary chain), Cortex creates an army of mutated animals and chooses Crash Bandicoot to lead them. Then, the second step is to brainwash them all with the Cortex Vortex.... except it doesn't work on Crash. After his plans are foiled by Crash, Cortex decides to join Megatron and work for the Decepticons. There, he met his brother Romeo from PJ Masks
- Cortex is Romeo (PJ Masks)'s brother.
- Dr. Neo Cortex is Ryvine Sparkle's father.
- Dr. Cortex will face Crash and Ryan in Ryan F-Freeman's Adventures of Transformers: Prime.
- Dr. Cortex will join forces with Ryvine and his friend, Rothbart in Crash, Thomas and Ryan Meets the Swan Princess.