Ed, Edd, n Eddy's Ed-ventures of The Powerpuff Grils: The Boys are Back in Town is a Cartoon Network crossover to be made by Stuingtion.
HIM is watching videos of The Powerpuff Girls defeating different villains. He gets angry when he sees something on one of the videos. The next day, the girls are fighting monsters and have just defeated them when a large outcropping emerges from the ground and on it are The Rowdyruff Boys! The girls are shocked to see that they are alive but they mock the boys' new hairstyles. They then start to fight, but the boys are too well matched so they try what they did to destroy them last time: be nice and kiss them. However, to their horror they discover that the boys are immune to them and they only make them bigger and more powerful. HIM then appears and tells them about how he gave the boys a cootie vaccination and he then leaves the girls intimidated by the boys, now 10 times their normal size.
The boys start to try and gross out Blossom, Bubbles, and Buttercup by cracking their knuckles, picking scabs and spitting. They then attack them leaving them battered and bruised and they squash them into a hockey puck. They play hockey with them until Boomer hits them into an indoor car park. The girls go up to the top of the building, but the boys find them and use them to play a game called Ultimate Fight. They then stick a slug up Bubbles' back which causes Buttercup to attack Butch and make him bite his tongue, and then Blossom gives her sisters the idea of embarrassing the Boys to make them shrink. Under the other's laughter and embarrassment he shrinks. When the girls see this they do all kinds of things to embarrass the boys and make them shrink down so they are smaller than the buckles of the girls shoes. HIM then appears again and shouts at the boys for not defeating the girls and he makes them disappear. He then tells the girls to watch their backs because they are back in town.