Miss Frizzle is adventurous and fun-loving teacher in Winnie the Pooh Enters The Magic School Bus. She often takes her students and Winnie the Pooh, Ash Ketchum, and their friends on crazy field trips and discover different things
- She is voiced by comedienne Lily Tomlin.
- Miss Frizzle will meet Aladar, his family, and his friends in Aladar Enters The Magic School Bus.
- Miss Frizzle will meet the FT Squad and allies in The FT Squad Rides on the Magic School Bus.
- Miss Frizzle, Liz, and her students will join Pooh, Ash, Littlefoot, Bloom, and their friends to face Bowser and his recruits in Pooh's Adventures of Disney Villains' Revenge.
- Miss Frizzle is also Cheerilee's first best friend.
- Miss Frizzle will first join Barney in Barney Takes You to Mr. Magorium's Wonder Emporium where she's revealed to old friends with both Barney and Mr. Magorium, who was Magorium's last apprentice before (Natalie Portman).