In the movie, Mittens forms a rather strange but nonetheless strong friendship with Bolt. At first, she hated the "crazy canine", constantly looking for ways to escape from him. At times, Bolt treated Mittens rather disrespectfully which aggravated their relation even more. But when Bolt finally gave up, admitting that he doesn't have any superpowers and doesn't know how to act like a dog, Mittens starts to feel bad for the mistreated dog, sympathizing with him out of knowing that he had been unfairly duped and he deserves to discover a life of his choosing. On their way back to Penny, Bolt and Mittens grew closer, and Mittens taught Bolt how to be a dog and enjoy life. She, however, deluded herself into thinking that Bolt will stay with her, settling down in Las Vagas so when Bolt decided to go on to Penny, she tell him to leave, with a heartbroken look on her face.
Mittens' true feelings for Bolt was never revealed or thoroughly explained in the movie, adding to the complex of their relationship, but is quite possible that Mittens fell in love with Bolt during their journey.
- Mittens will meet Pooh and his friends in Winnie the Pooh Meets Bolt.
- Mittens will guest star in Pooh's Adventures of The Mummy 3: Tomb of the Dragon Emperor.