Mrs. Brisby is the main character in Pooh's Adventures of The Secret of NIMH. She is the mother of Timothy Brisby and the widow of Jonathan Brisby. With the help from Winnie the Pooh, Ash Ketchum, and their friends, Mrs. Brisby struggles to save her family from a Plow and other threats.
- Mrs. Brisby will meet Littlefoot and his friends in Littlefoot's Adventures of The Secret of NIMH.
- Mrs. Brisby will meet Aladar, his family, and his friends in Aladar's Adventures of The Secret of NIMH.
- Mrs. Brisby appears in Logan and The Secret of NIMH.
- Mrs. Brisby becomes Fievel's adoptive mother after the evil Cat R. Waul killed Mama and Papa Mousekewitz.