Nova is a beautiful cocker spaniel who is one of Scooby-Doo's allies in Scooby-Doo! Mystery Incorporated! In the tv series, Scooby-Doo fell in love with Nova and stayed by her side. However, after she was severely injuried from falling out of the helicopter, she went into a big coma. Scooby visited her frequently. During one of his visits, the monitor turned off showing that she died. Suddenly she awoke and warned Scooby-Doo, "Nibiru is coming. Nibiru is coming!" It is revealed that interdimensional creatures called the Anunnaki possessed her and spoke through her mind, telling the gang about the Evil Entity and what it has done. She showed them the statue of the Hunters of Secrets and tells them that they were the most pure and the first to find out they were being manipulated. She even tells them the only way to save Crystal Cove is to find the Heart of the Jaguar and destroy the sarcophagus containing the Evil Entity. When the evil Anunnaki began terrorizing the town, Scooby believed that there is nothing they could do anymore and the Heart of the Jaguar was broken. But Nova didn't believe it because the spear was never truly the Heart of the Jaguar. The real Heart of the Jaguar was in fact the gang's friendship. After Scooby-Doo and the gang destroyed the Evil Entity, saved Crystal Cove and the universe, and created a new and improved timeline, Nova was still possessed by the Anunnaki and as the gang left to go to Miskatonic University, she thanked Scooby-Doo for his heroic actions and says that he is the most bravest dog that ever lived.
- She is voiced by Jennifer Hales as a dog while Amy Acker voices her while she is possessed by the Annunaki.
- Nova will meet Winnie the Pooh and his friends in Pooh's Adventures of Scooby-Doo! Mystery Incorperated!
- Nova will meet Ash Ketchum and his friends in Ash's Adventures of Scooby-Doo! Mystery Incorporated!
- Nova will meet Littlefoot and his friends in Littlefoot's Adventures of Scooby-Doo! Mystery Incorporated!