The show centers upon Zack and Cody Martin, twin brothers who live in the Tipton Hotel (Parody of the Hilton Hotel) in Boston, where their mother, Carey, sings and performs in the hotel lounge. However, it also centers upon the hotel owner's teenage daughter, London Tipton (A parody of Paris Hilton), who is very wealthy and ditzy, the hotel's down-to-earth candy-counter girl, Maddie Fitzpatrick, and Mr. Moseby, the strict, dutiful, and serious manager, who is often the foil to Zack and Cody's schemes and has a liking to the piano, pocket hankies and ballet The show is often set at the Tipton Hotel, but have other settings such as Zack and Cody's school, Cheevers High, and Maddie and London's private school, Our Lady of Perpetual Sorrow Catholic. Zack and Cody often get in trouble (sometimes unintentionally) and come up with witty ideas to get out of it.
- The 100 Acre Avatar League, Ash Ketchum, Pikachu, Misty, Togepi, Brock, Littlefoot, Cera, Ducky, Petrie, Spike, Chomper, Ruby, Guido, Grandpa Longneck, Grandma Longneck, Genie, Simba, Nala, Timon, Pumbaa, The Mighty Morphin Power Rangers, SpongeBob SquarePants, Patrick Star, Squidward Tentacles, Sandy Cheeks, Eugene Krabs, Harry Potter, Ronald Weasley ,Hermione Granger and The DigiDestined and their Digimon will guest star throw out the tire series.
- Korra and her friends (form The 100 Acre Avatar League), and Otis and his friends, The Human Mane 5, and Lincoln and his sister (from my Adventure team) will be absent in this series, due this is a past adventure.
- The Winnie the Pooh series, The Jungle Book, Pinocchio, The Lion King, Aladdin and Suite Life of Zake and Cody were all made by Disney.
- Suite Life of Zake and Cody was released their first season on Disney Channel in 2005 the same year both Pooh's Heffalump Movie and Harry Potter and the Goblet Of Fire were released in theaters and and air season 5 of The Fairly OddParents and Season 4 of SpongeBob SquarePants air on Nickelodeon.
- This series take place after Pooh's Adventures of Austin & Ally and Winnie the Pooh meets Jessie.
- The Storyline Counties in Pooh's Adventures of Suite Life on Deck and Pooh's Adventures of The Suite Life Movie.