Winnie the Pooh, Piglet, Tigger, Rabbit, Eeyore, The Vultures, Alex, Marty, Melman, Gloria, The Penguins of Madagascar, King Julien, Maurice, and Mort had just left Madagascar but they crash-landed in Africa where they met not only Pooh's friends named Simba, Nala, Timon, Pumbaa, Sora, Donald, and Goofy and Pooh's enemies The Hyenas, Arthur and Cecil, the Cheetas, Pete, and Scar but also Alex's mom and dad.
- Sora, Donald Duck, Goofy, Scar, Shenzi, Banzai, Ed, The Cheetahs, Arthur and Cecil, and Pete guest star in both versions of this film.
- The Vultures (Buzzie, Flaps, Dizzy, and Ziggy) and Jiminy Cricket guest star in the remake version of this film.
- This film actually takes place after Winnie the Pooh Meets Pinocchio (which explains Pooh and his friends already knowing Jiminy Cricket), and Ash's Adventures of Kingdom Hearts (which explains The Vultures already knowing Sora).
- LionKingRulezAgain1's original version was a PAL film with PAL bits from The Many Adventures of Winnie the Pooh, Pooh's Grand Adventure: The Search for Christopher Robin, The Tigger Movie, and Piglet's Big Movie and NTSC bits from Winnie the Pooh and Christmas Too, Pooh's Heffalump Movie, and The Lion King film. However, Daniel Esposito's upcoming remake version will be an NTSC film with NTSC bits from the Winnie the Pooh films, The Jungle Book 1 and 2, Pinocchio, Mickey's Christmas Carol, The Lion King films, A Goofy Movie, An Extremely Goofy Movie, and Mickey, Donald, Goofy: The Three Musketeers.
- Also known as Winnie the Pooh Goes to Madagascar: Escape 2 Africa.
- Both The Lion King and Madagascar: Escape 2 Africa featured music scores composed by Hans Zimmer.
- The storyline continues in Pooh's Adventures of Madagascar 3: Europe's Most Wanted and Pooh's Adventures of Penguins of Madagascar.