Ever since they were childhoods, Ash saved her by treating her injured knee. Moments later she became in love with Ash. And after she confess her feelings, she became Ash's girlfriend.
She and Daphne have a close bond, but they love fashion and have love interests.
Sora Takenouchi & Biyomon:
She, Sora Takenouchi and Biyomon are great friends.
Mimi Tachikawa & Palmon:
She, Mimi Tachikawa and Palmon are good friends, they love fashion.
Yolei Inoue & Hawkmon:
She, Yolei Inoue and Hawkmon are good friends.
Rika Nonaka & Renamon:
She, Rika and Renamon are good friends.
She and Zoe are great friends, they love fashion.
- She is voiced by Haven Pascall.
- Serena is mainly one of Ash's girlfriends in Ash's Adventures, alongside Misty, May, Dawn and Lillie.
- Serena will be mentioned by Ash during a conversation with Max Goof in Ash's Adventures of A Goofy Movie and will fully introduce her to him and his father in Pooh's Adventures of An Extremely Goofy Movie.
- Serena will make a surprise guest appearance at the end of Pooh's Adventures of Rugrats in Paris: The Movie.
- Serena will meet Team Robot in Team Robot In Pokemon XY The Series.
- In Noby Ran Away from Home: The Musical, she and May became rivals over Ash and who will be his girlfriend.
- Serena also confesses her love for him possibly in Pokemon XYZ The Series.
- In the series, Power Rangers Data Squad, Serena will have a love interest for Robbie in his brave courage and a strong heart.