This is how Symbiotes take over the bodies of the Mane Six goes in My Little Pony Transformers Bionicle: Rise of the Symbiotes.
[The Symbiote Queen approaches the friendship castle]
[The Symbiote Queen uses her tentacles to grab Twilight]
Twilight Sparkle: Let me go!
[The Symbiote Queen then uses her tentacles to grab Applejack, Pinkie Pie, Rarity, Fluttershy, and Rainbow Dash]
Applejack: Get off me!
Pinkie Pie: Let go!
Rarity: So filthy!
Rainbow Dash: Not cool.
[The Symbiote Queen decides to have them as the perfect test subjects for her childrens' new ability to take over a body and has one of her children go to Twilight and enters her body through her horn. The other Symbiotes then enter Applejack, Pinkie Pie, Rarity, Fluttershy, and Rainbow Dash's bodies through their wings, horn, and hooves]
[The Symbiote Queen then stands before her new followers]
Twilight Sparkle: My queen.
Applejack: Your wishes are our command.
Pinkie Pie: Equestria is within your reach.
Rarity: The magic of the princesses is weak.
Fluttershy: Without a change...
Rainbow Dash: You will poison Equestria.
[The Symbiote Queen cackles evilly]