In Sonic Lost World, Doctor Eggman harnesses the power of the Deadly Six in an attempt to defeat Sonic the Hedgehog and conquer the world. However, thanks to Sonic's recklessness, the Deadly Six rise up against Eggman and break free, threatening to destroy the world on their own. As a result, Eggman is forced to team up with Sonic in order to stop them for good, But Now, The Deadly Six are now Apprentice's to Master Xehanort
- Zavok is the leader of the Deadly Six, and the member behind the destruction of the world and the depletion of Sonic. He's got his eye on one thing, and that's world domination. Strong, clever, merciless and cruel, he possesses great fighting abilities. He is also the former apprentice of Master Zik.
- Zazz is one of the members of the Deadly Six in plans for the destruction of the world. He is the more short-tempered and hot-headed member of the six. He's nasty, ruthless, and crazily unpredictable. He loves to fight, and enjoys it more than eating three meals a day.
- Zeena is a member of the Deadly Six and the only female member. She is feeisty, cruel, cold-hearted, and is likely to complete a task when given one, though she has a terrifying temper that she is not shy about showing. She likes to look after herself and she’s not very likely to look after anyone else.
- Master Zik is the founder of the Deadly Six and as well the oldest member of the group. He is wise and normally taking it easy in his semi-retirement. However, he is a fighting genius, having been Zavok's teacher, allowing him to with the strength and agility of someone a fraction of his age. He was once called the "strongest warrior".
- Zomom is a member of the Deadly Six and the largest member of the six. He is a gluttonous Zeti who has strange powers, and will eat everything in sight. He's dull-witted and slow, but makes up for it with bone-crushing strength.
- Zor is a member of the Deadly Six. He's one with the shadows, both physically and mentally. He's the spy of the group, and carries a blue rose with him at all times. He's mean, moody, pessimistic, and nothing can amuse him. He utilizes powers so dark and forbidding, even the others would never use them.