The band leader, Dr. Teeth is a Elton John-based muppet character. He plays the keyboard and piano. He was played by Muppet creator Jim Henson, who did Ernie, Kermit, Rowlf, and others. Now he's played by Bill Barreta, who also does Pepe, Johnny Fiama, and several other Jim Henson muppets. He is #10 on WatchMojo.com's Top 10 Muppets from The Muppet Show. He is said to appear in the 2018 reboot of Muppet Babies.
The lead singer, Floyd is the grooviest member of the band. He plays bass, and his girlfriend in Janice. He was played by the late Jerry Nelson, who did Gobo and others. Now, he's being played by Matt Vogel, who does Robin, and other Jerry Nelson muppets.
Janice in the lead gutiar player, and Floyd's frequent girlfriend. Up until season 2 of The Muppet Show, she was played by a girl. Then she started being played by a boy, like Miss Piggy. First, she was played by Richard Hunt, who did Beaker and others. Now she's played by David Rudman, who does Baby Bear, Scooter and others.
A quiet jewish guy, Zoot plays sax in the band. He doesn't talk much, but he's said to be a "fifty-year-old burnt-out musician". He is played by Dave Goelz, who also does Gonzo and others.
Animal is the drummer party animal (thus his name) of the band. He's also often one of the lead Muppet characters, and one of the most popular. He speaks in few words and is really wild. He was one the muppts Frank Oz did, like Miss Piggy, Fozzie Bear, Bert, Grover, Cookie Monster, Sam the Eagle, and more, so now he's being voiced by Eric Jacobsen like the others, excluding Cookie (David Rudman). He is #2 on WatchMojo.com's Top 10 Muppets from The Muppet Show.
- Winnie the Pooh met the band in Pooh's Adventures of The Muppet Movie.
- Animal was part of the main cast of Muppet Babies. He was voiced by Howie Mandel in the first two seasons and Dave Coulier in the remainder. He will be voiced by Dee Bradley Baker in the 2018 reboot.
- The only other band member to appear in the original series was Janice, also voiced by Coulier. She appeared in the epiosde, Whose Tale Is This Anyway?.
- Archive footage of Dr. Teeth appeared in the episode Muppets Not Included. Teeth himself, however, has been said to appear in the 2018 reboot.