The Human Mane 5 are the human counterparts of Rainbow Dash, Applejack, Pinkie Pie, Fluttershy and Rarity.
Trivia
- The Human Mane 5 will meet Pooh and his friends in Pooh's Adventures of My Little Pony Equestria Girls.
- The Human Mane 5 will meet Thomas, Ash and their friends in Thomas' Adventures of My Little Pony: Equestria Girls.
- The Human Mane 5 will meet Emerl and his friends in Team Robot In Pokemon XY The Series.
- The Human Mane 5 will make their guest starring appearance in Pooh's Adventures of Thomas & Friends: Tale of the Brave, Winnie the Pooh and The Magic Roundabout, Pooh's Adventures of Mumfie's Quest: The Movie, Pooh's Adventures of Titan A.E., Winnie the Pooh Discovers Laputa: Castle in the Sky, Pooh's Adventures of Kiki's Delivery Service, Winnie the Pooh and The Trumpet of the Swan , Pooh's Adventures of Men in Black, Pooh's Adventures of Men in Black II, Pooh's Adventures of Men in Black III, Winnie the Pooh Enters The Polar Express, Winnie the Pooh Meets Spirit: Stallion of the Cimarron, Winnie the Pooh and a Journey to the Center of the Earth, Winnie the Pooh and a Journey 2: The Mysterious Island, Pooh's Adventures of Tom and Jerry: The Movie, and Winnie the Pooh meets Big Time Rush (Full Movie) whenever Twilight and her friends aren't available.
- The Human Mane 5 will join Pooh Adventures created by LegoKyle14 in the end of Winnie the Pooh goes Back at the Barnyard.
- The Human Mane 5 will make their guest starring appearance in Thomas the Tank Engine Meets the Hunchback of Notre Dame, Thomas' Adventures of We're Back: A Dinosaur's Story and Thomas' Adventures Chronicles whenever Twilight and her friends aren't available.
- The Human Mane 5 will meet Tino and his friends in Weekenders Adventures of My Little Pony: Equestria Girls.
- The Human Mane 5 will meet the TARDIS Team in Doctor Aaron's Adventures of My Little Pony: Equestria Girls.
- The Human Mane 5 will guest star in Doctor Aaron's Adventures of The Mummy Returns.