Thomas and Twilight Sparkle's Adventures of Avengers: Infinity War is an Thomas/MLP/Marvel crossover to be made by Stuington and co-directing by Hiatt Grey. And the sequel to Thomas and Twilight Sparkle's Adventures of Avengers: Age of Ultron and Ed, Edd, n Eddy's Ed-ventures of Avengers: Age of Ultron.
- Big Grizz, Steamy, Puffy, Evan, Shai-Shay, Rodger the logging loco, Rattlesnake Jake, 1206, Socky, Skunky, J.J., Buzz, Mako, Shema, Sharky, Willy, Mr. Great White, The Miner Trains, The Planet Trains, T.C., Hugs, Sherin, Marshall P.F., General Dedrich, The Trolley Fighters, Timber, Splinter, Chomper, Whiffle, Falcon, Ed, Edd, n Eddy, Spencer, Duck, Donald and Douglas, Oliver, Toad, Ryan, Ashima, Annie and Clarabel, Button Mash, Babs Seed, Zecora, Princess Celestia, Princess Luna, Coco Pommel, Cheese Sandwich, Princess Ember, Gabby, Stephen, Hiccup, Toothless, Astrid, Stormfly, Snotlout, Hookfang, Fishlegs, Meatlug, Ruffnut and Tuffnut, Barf and Belch, Team Griffin/Eeveelution Family, Peter Griffin, Glenn Quagmire, Cleveland Brown, Joe Swanson, Lois Griffin, Chris Griffin, Meg Griffin, Vinny Griffin, Stewie Griffin, Breon, Selena, Roger Smith, Bender Bending Rodriquez, Minerva Mink, Little Bear, Duck, Cat, Emily, Lucy, Doug Funnie, Skeeter Valentine, Natsu Dragneel, Lucy Heartfilia, Gray Fullbuster, Erza Scarlet, Wendy Marvell, Happy, Carla, Knockout, Puffer, Dolphy, Rachel, Mighty Joe, Daylight, Jenny, Pete, Kevin, Morley, Blitzer, Dile, Dusty Crophopper, Blythe Baxter, Zoe Trent, Gail Trent, Pepper Clark, Penny Ling, Sunil Nevla, Vinnie Terrio, Minka Mark, Russell Ferguson, Mitzi, Buttercream Sunday, Sugar Sprinkles, Nutmeg Dash, Youngmee Song, Sue Patterson, Jasper Jones, Jenny Wakeman, Dudley Puppy, Kitty Katswell, Hanah Streaker, Figge, Belle, Ariel, Jasmine, Merida, Mulan, Mushu, Mordecai, Rigby, Margaret, Eileen, Skips, Benson, Muscle Man, Skips, Hi-Five Ghost, Team Chugger, R3-X3 (Rax), Kanan Jarrus, Ezra Bridger, C1-10P (Chopper), Garazeb Orrelios, Sabine Wren, Hera Syndulla, Judy Hopps, Nick Wilde, Optimus Prime, Bumblebee, Ironhide, Ratchet, Sideswipe, Dino, Skids & Mudflap, Arcee, Hound, Cross-Hairs, Drift, and Wheelie and guest star in this film.
- Alter, Samantha & Slate, Megatron, Starscream, Shockwave, Soundwave, Sailor John, Drago, Drago's Bewilderbeast, Nightmare Moon, King Sombra, The Nightmare Train, The Evil Mane 6, Discord, Diesel 10, Diesel, The Dazzlings, Suri Polomare, Madame Pom LeBlanc, Diamond Tiara, Silver Spoon, The Biskit Twins, Cashmere and Velvet, Britt and Tiff Crust, Ripslinger, Ned and Ted, Dawn Bellwether, Trixie Lulamoon, Gilda, Lightning Dust, Starlight Glimmer, Queen Chrysalis, Katty Katswell, Ernie the Giant Chicken, Sideshow Bob, James Woods, Bobby Briggs, and Tirek will work for Thanos in this film
- Darth Maul makes a climax appearance in this film
- In order to be strong enough to face the Villains, Twilight will be turned into an alicorn but changed back to a unicorn in Thomas and Twilight Sparkle's Adventures of Avengers 4.
- The storyline concludes in Thomas and Twilight Sparkle's Adventures of Avengers 4.