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Tsunade is one of Konohagakure's legendary Sannin. Though celebrated as the world's most powerful kunoichi and its greatest medical-nin, Tsunade abandoned the life of the ninja for many years in pursuit of other goals. She is eventually persuaded to return to Konoha and becomes its Fifth Hokage (五代目火影, Godaime Hokage; Literally meaning "Fifth Fire Shadow"), where she uses her strength to repress the village's enemies and her medical knowledge to keep its villagers safe.

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