This is how Twilight's friends lose hope goes in My Little Pony Transformers Prime: The Return of Harmony.
Applejack: Alright girls, ready to use the Elements of Harmony?
Pinkie Pie: Yeah.
Rarity: Ready when you are, darling.
Fluttershy: I'm not sure. But I'm ready.
Rainbow Dash: Let's do this!
Twilight Sparkle: Don't care. They're not gonna work.
Thunderwing: Go on, then! Show me what you've got.
[The Elements of Harmony light up and the girls prepare to use the Elements on Thunderwing but they have no affect]
Applejack: What's going on?
Pinkie Pie: Mine's working.
Rarity: There must be something wrong with them.
Fluttershy: I don't understand.
Rainbow Dash: Why isn't this working?
Twilight Sparkle: I HATE the Element of Magic! Hmph! Garbage.
[Twilight throws the Element of Magic on the ground, which Optimus picks up then looks angrily at Thunderwing]
[Thunderwing claps while approaching the ponies and Autobots]
Thunderwing: Bravo, ponies, bravo! Harmony in Equestria is officially dead. Unicron rules, Celestia and Luna fall. [laughs]
[Thunderwing looks at Twilight, who's thinking about her friends]
Twilight Sparkle: It's your fault it didn't work.
Fluttershy: Who are you talking to?
Twilight Sparkle: [turns to her friends and the Autobots, who are standing behind her] All of you! I'm outta here! Now if you excuse me, I've got a new better friend to help create chaos for Lord Unicron. I'm sick of you losers.
[Twilight leaves to help Thunderwing spread chaos]
Applejack: FINE! Leave! See if we care!
Pinkie Pie: Yeah, we don't need you either!
Fluttershy: You were useless to us anyway!
Rainbow Dash: Yeah, with a friend like you, who needs...an enemy...?
[Applejack, Pinkie Pie, Rarity, Fluttershy, and Rainbow Dash's colors fade. A tear escapes their left eyes and takes the form of a broken heart]
[Applejack, Pinkie Pie, Rarity, Fluttershy, and Rainbow Dash walk through Ponyville when Thunderwing and Twilight appear]
Thunderwing: Element Wielders, you've got to see what Twilight and I just did.
[He and Twilight show them an upside down Equestria]
Thunderwing: It's priceless! [laughs]
Twilight Sparkle: Do you like it?
[Thunderwing sees Applejack, Pinkie Pie, Rarity, Fluttershy, and Rainbow Dash aren't impressed]
Thunderwing: Come now, Element Wielders, you've got to get into the spirit of things. After all, this is your new home.
[Applejack, Pinkie Pie, Rarity, Fluttershy, and Rainbow Dash look at their surroudings]
Applejack: Not anymore.
Pinkie Pie: How could we have been so selfish?
Rarity: We should have been better friends.
Rainbow Dash: Totally. Best friends forever.
[Applejack, Pinkie Pie, Rarity, Fluttershy, and Rainbow Dash continue walking through Ponyville]
Thunderwing: Yes! [triumphant laugh]
Twilight Sparkle: That's what we like to hear.