Yogi Bear, Cindy, Boo Boo and their friends have come back to Heaven, new come home of Charlie Barkin and Itchy Itchiford. During the visit, Gabriel's Horn is stolen. They go back to the real world and land in San Francisco, California. During their time on here, there meet a beautiful Irish Setter named Sasha La Fleur, whom Charlie falls in love with. They also meet Sasha's owner, David. Together, they must search the city for the Horn and stop a evil demonic Hellcat named Red (whom Dick Dastardly and Muttly work for) from getting his paws on it.